The AAPS Journal - Volume 6
Drug Addiction - From Basic Research to Therapies
(AAPS-NIDA Symposium Frontiers in Science, September 2004)

Editors: Rao S. Rapaka, Ph.D. (National Institute on Drug Abuse) and Wolfgang Sadée, Dr.rer.nat (Ohio State University)

Table of Contents

Abstracts

Using S-Tag Labeled Mu Opioid Receptor Peptides to Quantify the Interaction of G-protein Coupled Receptor Derived Peptides with Calmodulin
Ying Zhang, Danxin Wang, and Wolfgang Sadee

Preclinical Assessment of Monoamine Releasers as Treatments for Cocaine Dependence
S. Stevens Negus, Nancy Mello, Bruce Blough, Michael Baumann, and Richard Rothman

Measurement of mRNA Allelic Expression
Audrey Papp, Ying Zhang, Jeong-eun Lim, Andrew Johnson, Julia Pinsonneault, Gloria Smith, and Wolfgang Sadee

Small Cell-Permeable Peptides Interact with Stem-Loop II of the Hepatitis C Viral Internal Ribosome Entry Site and Inhibit Translation of Viral RNA
Alexander Birk, and Hazel Szeto

Quantitative Determination of Total and Free Concentrations of the Enantiomers of Methadone and its Metabolite (EDDP) in Human Plasma by Enantioselective Liquid Chromatography With Mass Spectrometric Detection
Maria Rodriguez-Rosas, Juan Medrano, David Epstein, Eric Moolchan, Kenzie Preston, and Irving Wainer

The Effects of Baclofen on Locomotor Activity Following Withdrawal from Continuous Cocaine Administration
Gail Pereira Do Carmo, George R. King, and Lindsay Mullins

Characterization of Candidate Genes Involved in Drug Addiction
Julia Pinsonneault, Audrey Papp, and Wolfgang Sadee

Mu Opioid Receptors Are Necessary for Cocaine-Induced Behavioral Sensitization and Conditioned Reinforcement
Ellen Unterwald, Michele Hummel, and Joseph Schroeder

An Anmal Model of Juvenile Nicotine Additiction in Rats Inhaling Cigarette Smoke for 7 Days
Janet Benson, Edward Barr, Jake McDonald, Matthew Campen, and Thomas Murray

Neoclerodane Diterpenes as Potential Drug Abuse Therapeutics
Kevin Tidgewell, Wayne Harding, Ken Holden, Christina Dersch, Eduardo Butelman, Richard Rothman, and Thomas Prisinzano

Synthesis and Pharmacological Evaluation of a Focused Combinatorial Library Based on the Kappa Opioid Receptor Antagonist Arodyn (Ac[Phe1,2,3,Arg4,D-Ala8]dynorphin A (1-11)NH2)
Jane A. Aldrich, Marco A. Bennett, and Thomas F. Murray

Ultra-low-dose Naltrexone Reduces the Abuse and Relapse Potential of Oxycodone in Rats
Francesco Leri, Benjamin Goddard, Zoe Rizos, and Lindsay H. Burns

Opioid Glycopeptide Analgesics. III. In Vivo Characterization of Antinociception and Other Behavioral Effects
Edward Bilsky, John Lowery, Richard Egleton, Muthu Dhanasekaran, and Robin Polt

A Unique Knock-in Mouse Model Carrying a Functional Dopamine Transporter that is Resistant to Cocaine
Howard Gu, Rong Chen, Michael Tilley, and Dawn Han

Opioid Glycopeptide Analgesics. I. Synthesis and Physiochemical Analysis
Robin Polt, Muthu Dhanasekaran, Richard Egleton, and Edward Bilsky

Opioid Glycopeptide Analgesics II: CNS Bioavailability and Delivery of Amphipathic Glycopeptides
Richard Egleton, Edward Bilsky, Muthu Dhanasekaran, and Robin Polt

Opioid/Chemokine Cross-Desensitization: A Therapeutic Opportunity?
Martin Adler, Ellen Geller, Xiao-Hong Chen, and Thomas Rogers

The Role of βarrestin2 in Morphine-Induced Inhibition of Gastrointestinal Transit
Kirsten M. Raehal, and Laura M. Bohn

Quantitative Assessment of Opioid Receptor Homo- and Hetero-dimerization in Living Cells by Bioluminescence Resonance Energy Transfer (BRET)
Danxin Wang, Xiaochun Sun, and Wolfgang Sadee

Salvinorin A, a Kappa Opioid Receptor Agonist, is a Fast Acting, Potent Analgesic
Christopher McCurdy, Kenneth Sufka, Jason Warnick, and Marcelo Nieto