The AAPS Journal - Themed Issue

The Role of Microdialysis in Pharmacokinetics and Pharmacodynamics
Guest Editors: Markus Müller and Ronald J. Sawchuk

Table of Contents

Toward the Prediction of CNS Drug-Effect Profiles in Physiological and Pathological Conditions Using Microdialysis and Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling
Elizabeth C.M. de Lange, Paulien G.M. Ravenstijn, Dorien Groenendaal, and Tamara J. van Steeg

Lung Microdialysis — A Powerful Tool for the Determination of Exogenous and Endogenous Compounds in the Lower Respiratory Tract (Mini-Review)
Markus Zeitlinger, Markus Müller, and Christian Joukhadar

In Vivo Microdialysis for PK and PD Studies of Anticancer Drugs
Qingyu Zhou and James M. Gallo

Microdialysis of Large Molecules
Geraldine F. Clough

The Chinchilla Microdialysis Model for the Study of Antibiotic Distribution to Middle Ear Fluid
Belinda W. Y. Cheung, Wei Liu, Ping Ji, Linda L. Cartier, Zhihong Li, Nael Mostafa, and Ronald J. Sawchuk

Microdialysis as a Tool in Local Pharmacodynamics
Yanjun Li, Joanna Peris, Li Zhong, and Hartmut Derendorf

Microdialysis Versus Other Techniques for the Clinical Assessment of In Vivo Tissue Drug Distribution
Martin Brunner and Oliver Langer