Volume 04, Issue 04

Special Issue Introductions 39 Introduction: A Welcome to the First Special Animal Health Issue of AAPS PharmSci Marilyn Martinez, Stefan Soback 43 Introduction: Pharmaceutics and Drug Delivery Bruce Aungst Articles 19 Preformulation Development of Recombinant Pegylated Staphylokinase SY161 Using Statistical Design Frank Bedu-Addo, Randall Moreadith, Siddharth J. Advant 20 Bioerodible Injectable Poly(ortho ester) for Tetracycline Controlled Delivery to Periodontal Pockets: Preliminary Trial in Humans K. Schwach-Abdellaoui, P. J. Loup, N. Vivien-Castioni, A. Mombelli, P. Baehni, J. Barr, J. Heller, R. Gurny 21 Monitoring Intracellular pH Changes in Response to Osmotic Stress and Membrane Transport Activity Using 5-Chloromethylfluorescein Aline Salvi, J. Mark Quillan, Wolfgang Sadée 22 Population Analysis of the Pharmacokinetics and Pharmacodynamics of RWJ-270201 (BCX-1812) in Treating Experimental Influenza A and B Virus in Healthy Volunteers Ganesh R. Iyer, Sam Liao, Joseph Massarella 23 Bioinformatic Analysis of the Human µ Opioid Receptor (OPRM1) Splice and Polymorphic Variants Lili Xin, Zaijie Jim Wang 24 Pharmacokinetics, Mass Balance, and Tissue Distribution of a Novel DNA Alkylating Agent, VNP40101M, in Rats John Mao, Yang Xu, Diana Wu, Bijan Almassain 25 Which Concentration of the Inhibitor Should Be Used to Predict In Vivo Drug Interactions From In Vitro Data? Kiyomi Ito, Koji Chiba, Masato Horikawa, Michi Ishigami, Naomi Mizuno, Jun Aoki, Yasumasa Gotoh, Takafumi Iwatsubo, Shin-ichi Kanamitsu, Motohiro Kato, Iichiro Kawahara, Kayoko Niinuma, Akiko Nishino, Norihito Sato, Yuko Tsukamoto, Kaoru Ueda, Tomoo Itoh, Yuichi Sugiyama 26 Peptide Delivery to the Brain via Adsorptive-Mediated Endocytosis: Advances With SynB Vectors Guillaume Drin, Christophe Rousselle, Jean-Michel Scherrmann, Anthony R Rees, Jamal Temsamani 27 Comparison of Stepwise Covariate Model Building Strategies in Population Pharmacokinetic-Pharmacodynamic Analysis Ulrika Wählby, E. Niclas Jonsson, Mats O. Karlsson 28 Effects of Obesity on the Pharmacodynamics of Nitroglycerin in Conscious Rats Ellen Q. Wang, Ho-Leung Fung 29 Detection of MDR1 Single Nucleotide Polymorphisms C3435T and G2677T Using Real-Time Polymerase Chain Reaction: MDR1 Single Nucleotide Polymorphism Genotyping Assay Pengfei Song, Shen Li, Bernd Meibohm, A.Osama Gaber, Marsha R. Honaker, Malak Kotb, Charles R. Yates 30 Role of Plasma Lipoproteins in Modifying the Toxic Effects of Water-Insoluble Drugs: Studies With Cyclosporine A Kishor M. Wasan, Manisha Ramaswamy, Mona Kwong, Kathy D. Boulanger 31 Quantitative Comparison of Functional Screening by Measuring Intracellular Ca2+With Radioligand Binding at Recombinant Human Dopamine Receptors Matthias U. Kassack 32 Linking Human and Veterinary Health: Trends, Directions and Initiatives Marilyn Martinez, Michael J Rathbone 33 Evolving Importance of Biologics and Novel Delivery Systems in the Face of Microbial Resistance Terry L. Bowersock 34 Interspecies Considerations in the Evaluation of Human Food Safety for Veterinary Drugs Arthur L. Craigmill, Kristy A. Cortright 35 Dissolution Test Development for Complex Veterinary Dosage Forms: Oral Boluses Raafat Fahmy, Bill Marnane, Dennis Bensley, R. Gary Hollenbeck 36 The Role of the Clinical Pharmacologist in Animal Health Cory Langston, Cyril R. Clarke 37 Impact of Antimicrobial Resistance on Regulatory Policies in Veterinary Medicine: Status Report Linda Tollefson, William T. Flynn 38 Pharmacokinetic/Pharmacodynamic Integration in Drug Development and Dosage-Regimen Optimization for Veterinary Medicine Pierre-Louis Toutain 40 An In Vitro Examination of the Impact of Polyethylene Glycol 400, Pluronic P85, and Vitamin E d-α-Tocopheryl Polyethylene Glycol 1000 Succinate on P-Glycoprotein Efflux and Enterocyte-Based Metabolism in Excised Rat Intestine Brendan M. Johnson, William N. Charman, Christopher J.H. Porter 41 Deposition of Nanoparticles in the Arterial Vessel by Porous Balloon Catheters: Localization by Confocal Laser Scanning Microscopy and Transmission Electron Microscopy Ulrich Westedt, Lucian Barbu-Tudoran, Andreas K. Schaper, Marc Kalinowski, Heiko Alfke, Thomas Kissel 42 Pharmacodynamic Modeling of Chemotherapeutic Effects: Application of a Transit Compartment Model to Characterize Methotrexate Effects in Vitro Evelyn D. Lobo, Joseph P. Balthasar 44 Chitosan and Sodium Alginate–Based Bioadhesive Vaginal Tablets Amal El-Kamel, Magda Sokar, Viviane Naggar, Safaa Al Gamal 45 A Thermogravimetric Analysis of Non-polymeric Pharmaceutical Plasticizers: Kinetic Analysis, Method Validation, and Thermal Stability Evaluation Aditya S. Tatavarti, David Dollimore, Kenneth S. Alexander 46 The Prediction of Plasma and Brain Levels of 2,3,5,6-Tetramethylpyrazine Following Transdermal Application Xiaohong Qi, Chrisita Ackermann, Duxin Sun, Rong (Ron) Liu, Minli Sheng, Huimin Hou

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