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| 65 | It’s Time
Brian P. Smith
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| 51 | Impact of Pharmacometrics on Drug Approval and Labeling Decisions: A Survey of 42 New Drug Applications
Venkatesh A. Bhattaram, Brian P. Booth, Roshni P. Ramchandani, B. Nhi Beasley, Yaning Wang, Veneeta Tandon, John Z. Duan, Raman K. Baweja, Patrick J. Marroum, Ramana S. Uppoor, Nam Atiqur Rahman, Chandrahas G. Sahajwalla, J. Robert Powell, Mehul U. Mehta, Jogarao V. S. Gobburu
[Abstract] [Full Text] [PDF] |
| 52 | Model-Based Development of Gemcabene, a New Lipid-Altering Agent
Jaap W. Mandema, David Hermann, Wenping Wang, Tim Sheiner, Mark Milad, Rebecca Bakker-Arkema, Daniel Hartman
[Abstract] [Full Text] [PDF] |
| 53 | A New Equivalence Based Metric for Predictive Check to Qualify Mixed-Effects Models
Pravin R. Jadhav, Jogarao V.S. Gobburu
[Abstract] [Full Text] [PDF] |
| 54 | Toward the Prediction of CNS Drug-Effect Profiles in Physiological and Pathological Conditions Using Microdialysis and Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling
Elizabeth C.M. de Lange, Paulien G.M. Ravenstijn, Dorien Groenendaal, Tamara J. van Steeg
[Abstract] [Full Text] [PDF] |
| 55 | Pharmacokinetics/Pharmacodynamics and the Stages of Drug Development: Role of Modeling and Simulation
Jenny Y. Chien, Stuart Friedrich, Michael A. Heathman, Dinesh P. de Alwis, Vikram Sinha
[Abstract] [Full Text] [PDF] |
| 56 | Opioid Peptide-Derived Analgesics
Peter W. Schiller
[Abstract] [Full Text] [PDF] |
| 58 | RNAi-directed Inhibition of DC-SIGN by Dendritic Cells: Prospects for HIV-1 Therapy
Madhavan P.N. Nair, Jessica L. Reynolds, Supriya D. Mahajan, Stanley A. Schwartz, Ravikumar Aalinkeel, B Bindukumar, Don Sykes
[Abstract] [Full Text] [PDF] |
| 59 | Recent Advances for the Treatment of Cocaine Abuse: Central Nervous System Immunopharmacotherapy
Tobin J. Dickerson, Kim D. Janda
[Abstract] [Full Text] [PDF] |
| 60 | Mu Opioid Receptor Regulation And Opiate Responsiveness
Kirsten M. Raehal, Laura M. Bohn
[Abstract] [Full Text] [PDF] |
| 61 | k Opioids as Potential Treatments for Stimulant Dependence
Thomas E. Prisinzano, Kevin Tidgewell, Wayne W. Harding
[Abstract] [Full Text] [PDF] |
| 62 | Lung Microdialysis–A Powerful Tool for the Determination of Exogenous and Endogenous Compounds in the Lower Respiratory Tract (Mini-Review)
Markus Zeitlinger, Markus Müller, Christian Joukhadar
[Abstract] [Full Text] [PDF] |
| 63 | Pharmacokinetic-Pharmacodynamic Modeling in the Data Analysis and Interpretation of Drug-induced QT/QTc Prolongation
Vladimir Piotrovsky
[Abstract] [Full Text] [PDF] |
| 64 | The Therapeutic Potential of Drugs That Target Cannabinoid Receptors or Modulate the Tissue Levels or Actions of Endocannabinoids
Roger G. Pertwee
[Abstract] [Full Text] [PDF] |
| 66 | In Vivo Microdialysis for PK and PD Studies of Anticancer Drugs
Qingyu Zhou, James M. Gallo
[Abstract] [Full Text] [PDF] |
| 68 | Molecular Modeling of mono- and bis-Quaternary Ammonium Salts as Ligands at the a4ß2* Nicotinic Acetylcholine Receptor Subtype Using Nonlinear Techniques
Joshua T. Ayers, Aaron Clauset, Jeffrey D. Schmitt, Linda P. Dwoskin, Peter A. Crooks
[Abstract] [Full Text] [PDF] |
| 69 | Microdialysis of Large Molecules
Geraldine F. Clough
[Abstract] [Full Text] [PDF] |
| 71 | Kappa Opioid Antagonists: Past Successes and Future Prospects
Matthew D. Metcalf, Andrew Coop
[Abstract] [Full Text] [PDF] |
| 73 | Regulation of Monoamine Transporters: Influence of Psychostimulants and Therapeutic Antidepressants
Lankupalle D. Jayanthi, Sammanda Ramamoorthy
[Abstract] [Full Text] [PDF] |
| 74 | Recognition of Psychostimulants, Antidepressants, and Other Inhibitors of Synaptic Neurotransmitter Uptake by the Plasma Membrane Monoamine Transporters
Christopher K. Surratt, Okechukwu T. Ukairo, Suneetha Ramanujapuram
[Abstract] [Full Text] [PDF] |
| 75 | A General Procedure for the Enantioselective Synthesis of the Minor Tobacco Alkaloids Nornicotine, Anabasine, and Anatabine
Joshua T. Ayers, Rui Xu, Linda P. Dwoskin, Peter A. Crooks
[Abstract] [Full Text] [PDF] |
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| 57 | Mucosal Delivery of Bacterial Antigens and CpG Oligonucleotides Formulated in Biphasic Lipid Vesicles in Pigs
Valeria Alcon, Maria Baca-Estrada, Marco Vega-Lopez, Philip Willson, Lorne A. Babiuk, Praveen Kumar, Rolf Hecker, Marianna Foldvari
[Abstract] [Full Text] [PDF] |
| 67 | Anion-induced Water Flux as Drug Release Mechanism Through Cationic Eudragit RS 30D Film Coatings
Karl G. Wagner, Ronny Gruetzmann
[Abstract] [Full Text] [PDF] |
| 70 | Population Pharmacokinetics of Recombinant Factor XIII in Cynomolgus Monkeys
Michael G. Dodds, Jennifer E. Visich, Paolo Vicini
[Abstract] [Full Text] [PDF] |
| 72 | Patent Issues in Drug Development: Perspectives of a Pharmaceutical Scientist-Attorney
Srikumaran Melethil
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